{"id":1876,"date":"2026-01-27T18:36:46","date_gmt":"2026-01-27T17:36:46","guid":{"rendered":"https:\/\/studienportal-eierstockkrebs.de\/engot-ov83-catalina-2\/"},"modified":"2026-02-13T12:11:00","modified_gmt":"2026-02-13T11:11:00","slug":"engot-ov83-catalina-2","status":"publish","type":"post","link":"https:\/\/studienportal-eierstockkrebs.de\/tr\/engot-ov83-catalina-2\/","title":{"rendered":"ENGOT-ov83 \/ CATALINA-2"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1876\" class=\"elementor elementor-1876 elementor-707\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4b75352e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4b75352e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cf9f728\" data-id=\"cf9f728\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-12254b72 elementor-widget elementor-widget-heading\" data-id=\"12254b72\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">ENGOT-ov83 \/ CATALINA-2<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52911afa elementor-widget elementor-widget-text-editor\" data-id=\"52911afa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"blue\"><strong>\u0130lerlemi\u015f, platine diren\u00e7li yumurtal\u0131k kanseri hastalar\u0131nda yeni bile\u015fik TORL-1-23&#8217;\u00fcn etkinli\u011fini ve g\u00fcvenli\u011fini de\u011ferlendirmek i\u00e7in terap\u00f6tik \u00e7al\u0131\u015fma<\/strong><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3899003 elementor-widget elementor-widget-text-editor\" data-id=\"3899003\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>CATALINA-2 <strong>, ilerlemi\u015f, platine diren\u00e7li yumurtal\u0131k kanseri <\/strong>(yumurtal\u0131k, fallop t\u00fcp\u00fc veya periton) olan kad\u0131nlarda <em>TORL-1-23<\/em> adl\u0131 yeni, hedefe y\u00f6nelik bir ilac\u0131 ara\u015ft\u0131ran uluslararas\u0131 bir faz 2 \u00e7al\u0131\u015fmad\u0131r. Bu, platin bazl\u0131 kemoterapiden sonra hastal\u0131\u011f\u0131n n\u00fcksetti\u011fi veya t\u00fcm\u00f6r\u00fcn art\u0131k kemoterapiye yan\u0131t vermedi\u011fi hastalar\u0131 ifade etmektedir. \u0130la\u00e7, t\u00fcm\u00f6r h\u00fccrelerinin y\u00fczeyinde bulunan ve <strong>claudin-6 (CLDN6)<\/strong> ad\u0131 verilen spesifik bir proteini hedef almaktad\u0131r. \u00c7al\u0131\u015fman\u0131n amac\u0131 <em>TORL-1-23<\/em> &#8216;\u00fcn ne kadar iyi \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 ve ne kadar iyi tolere edildi\u011fini test etmektir.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-69fa2007 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"69fa2007\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-48cd7a65\" data-id=\"48cd7a65\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-54f48f09 elementor-widget elementor-widget-text-editor\" data-id=\"54f48f09\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Bu \u00e7al\u0131\u015fmada ne analiz ediliyor?  <\/strong><\/p><p>Yumurtal\u0131k kanserinin tedavisi genellikle zordur, \u00f6zellikle de platin bazl\u0131 ila\u00e7larla (\u00f6rn. karboplatin) kemoterapiden sonra tekrarlarsa veya bu tedaviye duyars\u0131z hale gelmi\u015fse. Bu t\u00fcr vakalar platine diren\u00e7li yumurtal\u0131k kanseri olarak adland\u0131r\u0131l\u0131r. <\/p><p>Ara\u015ft\u0131rmac\u0131lar, claudin-6 (CLDN6) adl\u0131 spesifik bir proteinin bu t\u00fcm\u00f6rlerin \u00e7o\u011funda b\u00fcy\u00fck miktarlarda bulundu\u011funu ke\u015ffettiler. Bu protein normalde sadece h\u00fccre geli\u015fiminin \u00e7ok erken a\u015famalar\u0131nda bulunur ve sa\u011fl\u0131kl\u0131 dokuda nadiren bulunur. Bu nedenle CLDN6, sa\u011fl\u0131kl\u0131 dokuya ciddi zarar vermeden t\u00fcm\u00f6r h\u00fccrelerine spesifik olarak sald\u0131rmak i\u00e7in umut verici bir hedef olarak kabul edilmektedir.  <\/p><p><em>TORL-1-23<\/em>, antikor-ila\u00e7 konjugat\u0131 (ADC) olarak adland\u0131r\u0131lan bir ila\u00e7t\u0131r. Bu, ilac\u0131n t\u00fcm\u00f6r h\u00fccresi \u00fczerindeki CLDN6 proteinlerini spesifik olarak tan\u0131yan ve ba\u011flayan bir antikordan olu\u015ftu\u011fu anlam\u0131na gelmektedir. Antikora, t\u00fcm\u00f6r h\u00fccresine verilen ve oradaki kanser h\u00fccresini yok edebilen aktif bir madde ba\u011flanm\u0131\u015ft\u0131r.  <\/p><p>Daha \u00f6nceki bir faz 1 \u00e7al\u0131\u015fmas\u0131, TORL-1-23&#8217;\u00fcn iyi tolere edildi\u011fini ve CLDN6 ekspresyonu olan t\u00fcm\u00f6rlere kar\u015f\u0131 aktif olabilece\u011fini g\u00f6stermi\u015ftir. CATALINA-2 denemesi \u015fimdi ilac\u0131n daha b\u00fcy\u00fck bir hasta grubunda ne kadar etkili ve g\u00fcvenli oldu\u011funu ara\u015ft\u0131r\u0131yor. <\/p><p><strong>\u00c7al\u0131\u015fman\u0131n amac\u0131 nedir?  <\/strong><\/p><p>\u00c7al\u0131\u015fman\u0131n ana amac\u0131, tek tedavi (monoterapi) olarak <em>TORL-1-23<\/em> &#8216;\u00fcn hastal\u0131\u011f\u0131n ilerlemesini ne kadar geciktirdi\u011fini ve hastalar\u0131n tedaviden ne kadar s\u00fcre fayda g\u00f6rd\u00fc\u011f\u00fcn\u00fc bulmakt\u0131r.<br>Ayr\u0131ca, hangi dozaj\u0131n en iyi sonucu verdi\u011fini ve ayn\u0131 zamanda iyi tolere edildi\u011fini ara\u015ft\u0131rmak da ama\u00e7lanmaktad\u0131r.<\/p><p><strong>Anket nas\u0131l i\u015fliyor?<\/strong><\/p><p>CATALINA-2 \u00e7al\u0131\u015fmas\u0131 <strong>iki b\u00f6l\u00fcmden<\/strong> olu\u015fmaktad\u0131r:<\/p><ul><li><strong>B\u00f6l\u00fcm 1 (Doz bulma):<\/strong><br>Bu b\u00f6l\u00fcmde hangi <em>TORL-1-23<\/em> dozunun en iyi etkinlik ve tolerabilite kombinasyonunu g\u00f6sterdi\u011fi analiz edilmektedir. Bu ama\u00e7la, \u00fc\u00e7 farkl\u0131 kolda dozlar ara\u015ft\u0131r\u0131lmaktad\u0131r (kollardan birine tahsis randomize edilmi\u015ftir): <\/li><\/ul><p><strong>Kol 1:<\/strong> 2,4 mg <em>TORL-1-23<br><\/em><strong>Kol<\/strong> 2<strong>:<\/strong> 3,0 mg <em>TORL-1-23<br><\/em><strong>Kol<\/strong> 3<strong>:<\/strong> 3,4 mg <em>TORL-1-23<\/em><\/p><ul><li><strong>B\u00f6l\u00fcm 2 (etkinlik testi):<\/strong><br><em>TORL-1-23<\/em>, B\u00f6l\u00fcm 1&#8217;de belirlenen dozaj ile daha b\u00fcy\u00fck bir hasta grubunda test edilir.<\/li><\/ul><p><strong>Herhangi bir risk var m\u0131?<\/strong><\/p><p>Bir bilgilendirme oturumu s\u0131ras\u0131nda kat\u0131l\u0131mla ili\u015fkili olas\u0131 riskler ve yan etkiler hakk\u0131nda bilgilendirileceksiniz.<\/p><p><strong>Kat\u0131l\u0131m gereksinimleri<\/strong><\/p><p>Bu \u00e7al\u0131\u015fmaya 18 ya\u015f ve \u00fczeri kad\u0131nlar kat\u0131labilir:<\/p><ul><li>Platin bazl\u0131 tedavilere yan\u0131t vermeyen ilerlemi\u015f veya metastatik, y\u00fcksek dereceli yumurtal\u0131k, fallop t\u00fcp\u00fc veya primer periton kanseri tan\u0131s\u0131<\/li><li>T\u00fcm\u00f6r y\u00fczeyinde kan\u0131tlanm\u0131\u015f claudin-6 olu\u015fumu (\u00e7al\u0131\u015fman\u0131n bir par\u00e7as\u0131 olarak merkezi laboratuvar testi)<\/li><li>\u00c7al\u0131\u015fmaya giri\u015fte kan\u0131tlanm\u0131\u015f rezid\u00fcel t\u00fcm\u00f6r varl\u0131\u011f\u0131<\/li><\/ul><p>Bununla birlikte, \u00e7al\u0131\u015fmaya kat\u0131lmak i\u00e7in kar\u015f\u0131lanmas\u0131 gereken ba\u015fka kriterler de vard\u0131r. \u0130lgilenen hastalar, bu \u00e7al\u0131\u015fman\u0131n kendileri i\u00e7in uygun olup olmad\u0131\u011f\u0131n\u0131 kontrol edebilecek bir \u00e7al\u0131\u015fma merkezindeki ara\u015ft\u0131rmac\u0131larla konu\u015fmal\u0131d\u0131r. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6b2736ac elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6b2736ac\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-272c0ec4\" data-id=\"272c0ec4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-585ef27a elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"585ef27a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6333b954 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6333b954\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-11722dba\" data-id=\"11722dba\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3f415fc elementor-widget elementor-widget-text-editor\" data-id=\"3f415fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u00c7al\u0131\u015fmaya nerede kat\u0131labilirim?<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41526529 elementor-widget elementor-widget-button\" data-id=\"41526529\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"http:\/\/studienportal-eierstockkrebs.de\/deutschlandkarte\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-right\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M190.5 66.9l22.2-22.2c9.4-9.4 24.6-9.4 33.9 0L441 239c9.4 9.4 9.4 24.6 0 33.9L246.6 467.3c-9.4 9.4-24.6 9.4-33.9 0l-22.2-22.2c-9.5-9.5-9.3-25 .4-34.3L311.4 296H24c-13.3 0-24-10.7-24-24v-32c0-13.3 10.7-24 24-24h287.4L190.9 101.2c-9.8-9.3-10-24.8-.4-34.3z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Almanya haritas\u0131na<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a7ff48e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a7ff48e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-606bd31\" data-id=\"606bd31\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b00e94e elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b00e94e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-70301b1 elementor-widget elementor-widget-text-editor\" data-id=\"70301b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Son g\u00fcncelleme: 28.10.2025<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>ENGOT-ov83 \/ CATALINA-2 \u0130lerlemi\u015f, platine diren\u00e7li yumurtal\u0131k kanseri hastalar\u0131nda yeni bile\u015fik TORL-1-23&#8217;\u00fcn etkinli\u011fini ve g\u00fcvenli\u011fini de\u011ferlendirmek i\u00e7in terap\u00f6tik \u00e7al\u0131\u015fma CATALINA-2 , ilerlemi\u015f, platine diren\u00e7li yumurtal\u0131k kanseri (yumurtal\u0131k, fallop t\u00fcp\u00fc veya periton) olan kad\u0131nlarda TORL-1-23 adl\u0131 yeni, hedefe y\u00f6nelik bir ilac\u0131 ara\u015ft\u0131ran uluslararas\u0131 bir faz 2 \u00e7al\u0131\u015fmad\u0131r. Bu, platin bazl\u0131 kemoterapiden sonra hastal\u0131\u011f\u0131n n\u00fcksetti\u011fi veya t\u00fcm\u00f6r\u00fcn [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[47,46],"tags":[],"class_list":["post-1876","post","type-post","status-publish","format-standard","hentry","category-calismalar","category-nueks"],"acf":[],"_links":{"self":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/comments?post=1876"}],"version-history":[{"count":1,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1876\/revisions"}],"predecessor-version":[{"id":1880,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1876\/revisions\/1880"}],"wp:attachment":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/media?parent=1876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/categories?post=1876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/tags?post=1876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}