{"id":1975,"date":"2026-01-27T18:10:09","date_gmt":"2026-01-27T17:10:09","guid":{"rendered":"https:\/\/studienportal-eierstockkrebs.de\/nis-carolin\/"},"modified":"2026-02-13T12:22:14","modified_gmt":"2026-02-13T11:22:14","slug":"nis-carolin","status":"publish","type":"post","link":"https:\/\/studienportal-eierstockkrebs.de\/tr\/nis-carolin\/","title":{"rendered":"NIS CAROLIN"},"content":{"rendered":"\t\t
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NIS Niraparib - NOGGO-ov45 - CAROLIN<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Platine duyarl\u0131 yumurtal\u0131k kanseri olan ve niraparib i\u00e7in kontrendikasyonu bulunmayan hastalar i\u00e7in<\/strong><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t
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Bu giri\u015fimsel olmayan g\u00f6zlemsel \u00e7al\u0131\u015fman\u0131n<\/span> amac\u0131, ilk kez tan\u0131 konmu\u015f veya n\u00fcksetmi\u015f<\/strong> platine duyarl\u0131 yumurtal\u0131k kanseri hastalar\u0131nda niraparib ile uzun s\u00fcreli tedaviyi<\/strong> ara\u015ft\u0131rmak ve uzun s\u00fcreli sa\u011fkal\u0131m ile ili\u015fkili fakt\u00f6rleri belirlemektir. Niraparib, kemoterapi taraf\u0131ndan hasar g\u00f6ren kanser h\u00fccrelerindeki onar\u0131m mekanizmalar\u0131n\u0131 bask\u0131layarak kemoterapinin tamamlanmas\u0131ndan sonra etkisini uzatan PARP inhibit\u00f6r\u00fc<\/span> olarak adland\u0131r\u0131lan bir ila\u00e7t\u0131r. Hasarl\u0131 h\u00fccreler daha sonra yenilenemez ve bunun yerine \u00f6l\u00fcrler. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Anketin amac\u0131 nedir?<\/strong><\/p>

Ama\u00e7, hastal\u0131\u011fa, tedaviye ve hastalara ili\u015fkin hangi tipik \u00f6zelliklerin\/ karakteristiklerin uzun s\u00fcreli sa\u011fkal\u0131mla ili\u015fkili oldu\u011funu bulmakt\u0131r. Ayr\u0131ca niraparib uygulamas\u0131n\u0131n hangi tedaviye \u00f6zg\u00fc fakt\u00f6rlerinin (doz, yan etkiler, tedavi s\u00fcresi, tedavi s\u0131ras\u0131ndaki ya\u015fam kalitesi) uzun s\u00fcreli sa\u011fkal\u0131m ile ili\u015fkili oldu\u011funu ara\u015ft\u0131r\u0131yoruz. <\/p>

\u00c7al\u0131\u015fma nas\u0131l organize edildi?<\/strong><\/p>

Bu, niraparib ile tedavi karar\u0131n\u0131n \u00e7al\u0131\u015fman\u0131n ba\u015flang\u0131c\u0131ndan \u00f6nce doktor ve hasta taraf\u0131ndan verildi\u011fi ve tedavinin standart rejime g\u00f6re y\u00fcr\u00fct\u00fcld\u00fc\u011f\u00fc g\u00f6zlemsel<\/strong> bir \u00e7al\u0131\u015fmad\u0131r<\/strong>. Hasta verileri \u00e7al\u0131\u015fman\u0131n ba\u015flang\u0131c\u0131nda ve \u00e7al\u0131\u015fmaya dahil edildikten sonra sekiz y\u0131la kadar her alt\u0131 ayda bir toplanacakt\u0131r. <\/p>

Herhangi bir risk var m\u0131?<\/strong><\/p>

Bu tamamen g\u00f6zlemsel bir \u00e7al\u0131\u015fmad\u0131r, yani hastalar herhangi bir ek ila\u00e7 veya ba\u015fka tedavi rejimi almamaktad\u0131r. Bu bak\u0131mdan, \u00e7al\u0131\u015fma kat\u0131l\u0131mc\u0131lar\u0131 herhangi bir ek risk veya yan etkiye maruz kalmamaktad\u0131r. Bununla birlikte, kemoterapi sonras\u0131 n\u00fcks durumunda yumurtal\u0131k kanseri olan hastalara re\u00e7ete edilen niraparib ile tedavinin yan etkileri olabilir, \u00f6rne\u011fin kan trombositlerinin eksikli\u011fine, belirli beyaz kan h\u00fccrelerinin (n\u00f6trofil gran\u00fclositler) eksikli\u011fine, anemiye, y\u00fcksek tansiyona veya yorgunluk sendromuna yol a\u00e7abilir. <\/p>

Kat\u0131l\u0131m gereksinimleri<\/strong><\/p>

\u0130lk kez tan\u0131 konmu\u015f veya n\u00fcks etmi\u015f (histolojik bulgularla do\u011frulanm\u0131\u015f) ve kemoterapi sonucunda t\u00fcm\u00f6r yan\u0131t\u0131 elde etmi\u015f yumurtal\u0131k, fallop t\u00fcp\u00fc veya periton kanseri olan 18 ya\u015f ve \u00fczeri kad\u0131nlar bu \u00e7al\u0131\u015fmaya kat\u0131labilir. Hastalar niraparib ile idame tedavisi<\/span> i\u00e7in uygun olmal\u0131d\u0131r, yani kontrendikasyonlar\u0131 olmamal\u0131 ve oral ila\u00e7lar\u0131 ba\u011f\u0131ms\u0131z ve g\u00fcvenilir bir \u015fekilde alabilmelidir. \u0130laca kar\u015f\u0131 a\u015f\u0131r\u0131 hassasiyeti olan, hamile veya emziren hastalar\u0131n \u00e7al\u0131\u015fmaya kat\u0131lmas\u0131na izin verilmez. <\/p>

\u00c7al\u0131\u015fmalara nerede kat\u0131labilirim?<\/strong><\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Bu \u00e7al\u0131\u015fma taraf\u0131ndan desteklenmektedir:<\/strong><\/p>

Ara\u015ft\u0131rmaya dayal\u0131 ila\u00e7 \u015firketi GLAXOSMITHKLINE <\/strong> bu \u00e7al\u0131\u015fman\u0131n orta\u011f\u0131d\u0131r.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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NIS Niraparib – NOGGO-ov45 – CAROLIN Platine duyarl\u0131 yumurtal\u0131k kanseri olan ve niraparib i\u00e7in kontrendikasyonu bulunmayan hastalar i\u00e7in Bu giri\u015fimsel olmayan g\u00f6zlemsel \u00e7al\u0131\u015fman\u0131n amac\u0131, ilk kez tan\u0131 konmu\u015f veya n\u00fcksetmi\u015f platine duyarl\u0131 yumurtal\u0131k kanseri hastalar\u0131nda niraparib ile uzun s\u00fcreli tedaviyi ara\u015ft\u0131rmak ve uzun s\u00fcreli sa\u011fkal\u0131m ile ili\u015fkili fakt\u00f6rleri belirlemektir. Niraparib, kemoterapi taraf\u0131ndan hasar g\u00f6ren kanser […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[47,45],"tags":[],"class_list":["post-1975","post","type-post","status-publish","format-standard","hentry","category-calismalar","category-birincil-durum"],"acf":[],"_links":{"self":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1975","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/comments?post=1975"}],"version-history":[{"count":1,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1975\/revisions"}],"predecessor-version":[{"id":1980,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1975\/revisions\/1980"}],"wp:attachment":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/media?parent=1975"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/categories?post=1975"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/tags?post=1975"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}