{"id":1979,"date":"2025-10-21T23:05:16","date_gmt":"2025-10-21T21:05:16","guid":{"rendered":"https:\/\/studienportal-eierstockkrebs.de\/esmo-2025ten-yeni-calisma-verileri-immuenoterapi-platine-direncli-yumurtalik-kanserinde-ilk-kez-sagkalim-faydasi-sagliyor\/"},"modified":"2026-02-13T12:22:14","modified_gmt":"2026-02-13T11:22:14","slug":"esmo-2025ten-yeni-calisma-verileri-immuenoterapi-platine-direncli-yumurtalik-kanserinde-ilk-kez-sagkalim-faydasi-sagliyor","status":"publish","type":"post","link":"https:\/\/studienportal-eierstockkrebs.de\/tr\/esmo-2025ten-yeni-calisma-verileri-immuenoterapi-platine-direncli-yumurtalik-kanserinde-ilk-kez-sagkalim-faydasi-sagliyor\/","title":{"rendered":"ESMO 2025&#8217;ten yeni \u00e7al\u0131\u015fma verileri &#8211; \u0130mm\u00fcnoterapi platine diren\u00e7li yumurtal\u0131k kanserinde ilk kez sa\u011fkal\u0131m faydas\u0131 sa\u011fl\u0131yor"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1979\" class=\"elementor elementor-1979 elementor-1138\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e438c86 e-flex e-con-boxed e-con e-parent\" data-id=\"e438c86\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2cf51b7 elementor-widget elementor-widget-heading\" data-id=\"2cf51b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\"><strong>ESMO 2025'ten yeni \u00e7al\u0131\u015fma verileri<\/strong><br>\u0130mm\u00fcnoterapi, <br>platine diren\u00e7li yumurtal\u0131k kanserinde ilk sa\u011fkal\u0131m faydas\u0131n\u0131 sa\u011fl\u0131yor<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe93418 elementor-widget elementor-widget-image\" data-id=\"fe93418\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"625\" height=\"156\" src=\"https:\/\/studienportal-eierstockkrebs.de\/wp-content\/uploads\/esmo-congress-2025-700x175-1.jpg\" class=\"attachment-large size-large wp-image-1981\" alt=\"\" srcset=\"https:\/\/studienportal-eierstockkrebs.de\/wp-content\/uploads\/esmo-congress-2025-700x175-1.jpg 700w, https:\/\/studienportal-eierstockkrebs.de\/wp-content\/uploads\/esmo-congress-2025-700x175-1-300x75.jpg 300w, https:\/\/studienportal-eierstockkrebs.de\/wp-content\/uploads\/esmo-congress-2025-700x175-1-624x156.jpg 624w\" sizes=\"(max-width: 625px) 100vw, 625px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-070f551 elementor-widget elementor-widget-text-editor\" data-id=\"070f551\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"254\" data-end=\"677\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\"> <strong>ENGOT-ov65\/KEYNOTE-B96<\/strong> \u00e7al\u0131\u015fmas\u0131n\u0131n ilk sonu\u00e7lar\u0131na ili\u015fkin bir bas\u0131n b\u00fclteni May\u0131s 2025&#8217;te yay\u0131nlanm\u0131\u015f ve en son umut verici sonu\u00e7lar hafta sonu Berlin&#8217;de d\u00fczenlenen ESMO Kongresi&#8217;nde sunulmu\u015ftur. <\/span>Bu uluslararas\u0131 faz III \u00e7al\u0131\u015fmada, <strong data-start=\"457\" data-end=\"474\">pembrolizumab<\/strong> (bir imm\u00fcn kontrol noktas\u0131 inhibit\u00f6r\u00fc) ve <strong data-start=\"513\" data-end=\"527\">paklitaksel<\/strong> (bir kemoterap\u00f6tik ajan) kombinasyonunun, <strong data-start=\"570\" data-end=\"585\">bevacizumab<\/strong> (bir anjiyogenez inhibit\u00f6r\u00fc) ile birlikte veya tek ba\u015f\u0131na, <strong>platine diren\u00e7li yumurtal\u0131k kanseri <\/strong>hastalar\u0131n\u0131n sa\u011fkal\u0131m\u0131n\u0131 uzat\u0131p uzatamayaca\u011f\u0131 ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.<\/p><p data-start=\"679\" data-end=\"1202\">Sonu\u00e7lar g\u00f6steriyor ki: <strong data-start=\"730\" data-end=\"768\">Progresyonsuz sa\u011fkal\u0131mdaki (PFS)<\/strong> kazan\u00e7, yani hastal\u0131\u011f\u0131n b\u00fcy\u00fcmeye devam etti\u011fi s\u00fcre yakla\u015f\u0131k <strong data-start=\"829\" data-end=\"842\">2 ay<\/strong> gibi olduk\u00e7a k\u00fc\u00e7\u00fck olsa da, bu fark klinik a\u00e7\u0131dan \u00f6nemliydi. Bununla birlikte, <strong data-start=\"938\" data-end=\"986\">genel sa\u011fkal\u0131mdaki (OS) \u00f6nemli avantaj<\/strong> belirleyicidir: t\u00fcm\u00f6rleri <strong data-start=\"1016\" data-end=\"1033\">PD-L1-pozitif<\/strong> (imm\u00fcnoterapiye yan\u0131t i\u00e7in bir belirte\u00e7) olan hastalar, sadece kemoterapi alan kar\u015f\u0131la\u015ft\u0131rma grubundaki <strong data-start=\"1130\" data-end=\"1146\">14,0 aya<\/strong> k\u0131yasla ortalama <strong data-start=\"1104\" data-end=\"1119\">18,2 ay<\/strong> ya\u015fam\u0131\u015ft\u0131r. <\/p><p data-start=\"1204\" data-end=\"1462\">Bu, \u00f6nceki tedavilerin genellikle sadece k\u0131sa vadede etkili oldu\u011fu bu zor hastal\u0131kta ilk kez imm\u00fcnoterapi ile ger\u00e7ek bir sa\u011fkal\u0131m faydas\u0131n\u0131n g\u00f6sterildi\u011fi ve bunun \u00f6nceden se\u00e7ilmemi\u015f bir hasta grubunda yap\u0131ld\u0131\u011f\u0131 anlam\u0131na gelmektedir.<\/p><p data-start=\"1464\" data-end=\"1765\">Kombinasyon tedavisinin <strong data-start=\"1473\" data-end=\"1494\">g\u00fcvenlik profili<\/strong> de genel olarak <strong data-start=\"1534\" data-end=\"1548\">kabul edilebilirdi<\/strong>, ancak hastalar\u0131n yakla\u015f\u0131k \u00fc\u00e7te ikisinde 3. derece veya daha y\u00fcksek yan etkiler meydana geldi. \u00d6zellikle dikkat \u00e7ekici olan: sa\u011fkal\u0131m faydas\u0131, bevacizumab\u0131n da verilip verilmedi\u011finden <strong data-start=\"1692\" data-end=\"1712\">ba\u011f\u0131ms\u0131zd\u0131<\/strong>. <\/p><p data-start=\"1767\" data-end=\"2047\">Uzmanlar bu verileri platine diren\u00e7li yumurtal\u0131k kanserinin tedavisinde potansiyel bir d\u00f6n\u00fcm noktas\u0131 olarak g\u00f6r\u00fcyor. \u015eimdiye kadar imm\u00fcnoterapilerin bu kanser t\u00fcr\u00fcndeki etkinli\u011fi s\u0131n\u0131rl\u0131yd\u0131. Bu durum, \u00f6zellikle <strong data-start=\"2019\" data-end=\"2046\">PD-L1-pozitif t\u00fcm\u00f6rl\u00fc<\/strong> hastalar i\u00e7in art\u0131k de\u011fi\u015febilir.  <\/p><p data-start=\"2049\" data-end=\"2392\">Bununla birlikte, Dr. Rebecca Kristeleit (Londra) gibi uzmanlar sonu\u00e7lar\u0131n dikkatle yorumlanmas\u0131 gerekti\u011fini vurgulamaktad\u0131r. Klinik fayda, olas\u0131 yan etkiler ve maliyetler kar\u015f\u0131s\u0131nda tart\u0131lmal\u0131d\u0131r. Bu kombinasyonun gelecekte ruhsatland\u0131r\u0131l\u0131p ruhsatland\u0131r\u0131lmayaca\u011f\u0131 ya da sadece belirli alt gruplar i\u00e7in tavsiye edilip edilemeyece\u011fi de hen\u00fcz belli de\u011fildir.  <\/p><p data-start=\"2394\" data-end=\"2675\">Son olarak, Berlin&#8217;de <strong data-start=\"2433\" data-end=\"2469\">gelecekteki kombinasyon tedavileri<\/strong> de tart\u0131\u015f\u0131ld\u0131: <strong data-start=\"2493\" data-end=\"2534\">Antikor-ila\u00e7 konjugatlar\u0131 (ADC<\/strong> &#8216;ler) gelecekte imm\u00fcnoterapilerle birlikte kullan\u0131labilir ve b\u00f6ylece bu zor t\u00fcm\u00f6r t\u00fcr\u00fcne sahip hastalar i\u00e7in daha fazla umut sunabilir.<\/p><p data-start=\"2394\" data-end=\"2675\">Kaynak: <a href=\"https:\/\/dailyreporter.esmo.org\/esmo-congress-2025\/gynaecological-tumours\/survival-benefits-demonstrated-with-immunochemotherapy-in-platinum-resistant-ovarian-cancer\" target=\"_blank\" rel=\"noopener\">ESMO Kongre Raporu<\/a> (makale \u0130ngilizcedir)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>ESMO 2025&#8217;ten yeni \u00e7al\u0131\u015fma verileri\u0130mm\u00fcnoterapi, platine diren\u00e7li yumurtal\u0131k kanserinde ilk sa\u011fkal\u0131m faydas\u0131n\u0131 sa\u011fl\u0131yor ENGOT-ov65\/KEYNOTE-B96 \u00e7al\u0131\u015fmas\u0131n\u0131n ilk sonu\u00e7lar\u0131na ili\u015fkin bir bas\u0131n b\u00fclteni May\u0131s 2025&#8217;te yay\u0131nlanm\u0131\u015f ve en son umut verici sonu\u00e7lar hafta sonu Berlin&#8217;de d\u00fczenlenen ESMO Kongresi&#8217;nde sunulmu\u015ftur. Bu uluslararas\u0131 faz III \u00e7al\u0131\u015fmada, pembrolizumab (bir imm\u00fcn kontrol noktas\u0131 inhibit\u00f6r\u00fc) ve paklitaksel (bir kemoterap\u00f6tik ajan) kombinasyonunun, bevacizumab [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":1864,"comment_status":"closed","ping_status":"closed","sticky":true,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[49,1],"tags":[],"class_list":["post-1979","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-haberler","category-nicht-kategorisiert"],"acf":[],"_links":{"self":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1979","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/comments?post=1979"}],"version-history":[{"count":1,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1979\/revisions"}],"predecessor-version":[{"id":1982,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1979\/revisions\/1982"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/media\/1864"}],"wp:attachment":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/media?parent=1979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/categories?post=1979"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/tags?post=1979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}