{"id":1984,"date":"2026-01-27T18:26:22","date_gmt":"2026-01-27T17:26:22","guid":{"rendered":"https:\/\/studienportal-eierstockkrebs.de\/ago-ovar-2-46-engot-ov81-ramp-301\/"},"modified":"2026-02-13T12:22:16","modified_gmt":"2026-02-13T11:22:16","slug":"ago-ovar-2-46-engot-ov81-ramp-301","status":"publish","type":"post","link":"https:\/\/studienportal-eierstockkrebs.de\/tr\/ago-ovar-2-46-engot-ov81-ramp-301\/","title":{"rendered":"AGO-OVAR 2.46 \/ ENGOT-ov81 \/ RAMP 301"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1984\" class=\"elementor elementor-1984 elementor-646\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4b75352e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4b75352e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cf9f728\" data-id=\"cf9f728\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-12254b72 elementor-widget elementor-widget-heading\" data-id=\"12254b72\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">AGO-OVAR 2.46 \/ ENGOT-ov81 \/ RAMP 301<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52911afa elementor-widget elementor-widget-text-editor\" data-id=\"52911afa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"blue\"><strong>TEKRARLAYAN D\u00dc\u015e\u00dcK DERECELI\u0307 SER\u00d6Z OVER KARSI\u0307NOMU \u00dcZERI\u0307NE KLI\u0307NI\u0307K \u00c7ALI\u015eMA<\/strong><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-737fc73 e-flex e-con-boxed e-con e-parent\" data-id=\"737fc73\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-61a7781 elementor-widget elementor-widget-text-editor\" data-id=\"61a7781\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>AGO-OVAR 2.46 \/ ENGOT-ov81 \/ RAMP 301, tekrarlayan d\u00fc\u015f\u00fck dereceli ser\u00f6z over kanseri (LGSOC) olan hastalarda ara\u015ft\u0131rmac\u0131n\u0131n se\u00e7ti\u011fi tedaviye k\u0131yasla <em>avutometinib<\/em> ve <em>defaktinib<\/em> kombinasyon tedavisinin randomize, a\u00e7\u0131k etiketli bir faz III \u00e7al\u0131\u015fmas\u0131d\u0131r.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-69fa2007 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"69fa2007\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-48cd7a65\" data-id=\"48cd7a65\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-54f48f09 elementor-widget elementor-widget-text-editor\" data-id=\"54f48f09\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u00c7al\u0131\u015fman\u0131n amac\u0131 nedir?<\/strong><\/p><p>Bu \u00e7al\u0131\u015fma, \u00f6nceki tedaviden sonra geri d\u00f6nen d\u00fc\u015f\u00fck dereceli ser\u00f6z yumurtal\u0131k kanseri olan kad\u0131nlar i\u00e7in yeni bir kombinasyon tedavisini ara\u015ft\u0131rmaktad\u0131r. Ama\u00e7, bu yeni tedavinin mevcut standart tedavilerden daha iyi sonu\u00e7 verip vermedi\u011fini belirlemektir. LGSOC i\u00e7in kemoterapi ve hormon tedavisi gibi mevcut tedaviler her zaman istenildi\u011fi kadar etkili olmayabilir. Bu nedenle bu \u00e7al\u0131\u015fma, LGSOC hastalar\u0131nda kanser b\u00fcy\u00fcmesini yava\u015flatma veya durdurmada daha iyi olup olmad\u0131klar\u0131n\u0131 g\u00f6rmek i\u00e7in yeni bir ara\u015ft\u0131rma ila\u00e7lar\u0131 kombinasyonu olan <em>avutometinib<\/em> ve <em>defaktinib<\/em>&#8216;i ara\u015ft\u0131rmaktad\u0131r. Her iki ila\u00e7 da kinaz inhibit\u00f6rleridir &#8211; kanser h\u00fccrelerinin b\u00fcy\u00fcmek i\u00e7in kulland\u0131\u011f\u0131 belirli sinyal yollar\u0131n\u0131 hedef alan ila\u00e7lar.    <\/p><p><strong>Anket nas\u0131l i\u015fliyor?<\/strong><\/p><p>\u00c7al\u0131\u015fma sizin i\u00e7in uygunsa ve kat\u0131lmaya karar verirseniz:<\/p><p>Ara\u015ft\u0131r\u0131lmakta olan yeni kombinasyon tedavisine ya da doktorunuz taraf\u0131ndan se\u00e7ilen birka\u00e7 standart tedaviden birine rastgele atanacaks\u0131n\u0131z.<\/p><p><strong>Grup 1:<\/strong> Haftada iki kez <em>avutometinib<\/em> ve g\u00fcnde iki kez tablet formunda <em>defaktinib<\/em> alacaks\u0131n\u0131z. Bu ila\u00e7lar \u00fc\u00e7 hafta boyunca al\u0131n\u0131r, ard\u0131ndan bir haftal\u0131k bir ara verilir ve bunlar birlikte bir d\u00f6ng\u00fc olu\u015fturur. <\/p><p><strong>Grup 2:<\/strong> LGSOC i\u00e7in standart bak\u0131m. Doktorunuzun \u00f6nerisine g\u00f6re kemoterapi veya hormon tedavisi gibi \u015fu anda mevcut olan tedavilerden biri. <\/p><p>Sa\u011fl\u0131\u011f\u0131n\u0131z\u0131 ve kanserinizi izlemek i\u00e7in d\u00fczenli muayeneler, taramalar ve kan testlerinden ge\u00e7eceksiniz. Kat\u0131l\u0131m\u0131n\u0131z\u0131n s\u00fcresi v\u00fccudunuzun tedaviye nas\u0131l yan\u0131t verdi\u011fine ba\u011fl\u0131 olacakt\u0131r. Kanserinizi kontrol etmeye yard\u0131mc\u0131 oldu\u011fu ve herhangi bir yan etkiyi tolere edebildi\u011finiz s\u00fcrece deneme tedavisini almaya devam edeceksiniz.  <\/p><p>Grup 2&#8217;ye atan\u0131rsan\u0131z ve tedavi s\u0131ras\u0131nda kanseriniz k\u00f6t\u00fcle\u015firse, Grup 1&#8217;e ge\u00e7meye uygun olabilirsiniz. Tedaviniz sona erdikten sonra bile sa\u011fl\u0131\u011f\u0131n\u0131z\u0131 izlemek i\u00e7in 5 y\u0131la kadar takip edileceksiniz. <\/p><p><strong>Herhangi bir risk var m\u0131?<\/strong><\/p><p>Yeni tedavi, baz\u0131lar\u0131 ciddi olabilen yan etkilere neden olabilir, \u00f6rne\u011fin cilt reaksiyonlar\u0131, sindirim sorunlar\u0131, g\u00f6z sorunlar\u0131.<br>Yeni tedavi, standart tedaviler kadar iyi sonu\u00e7 vermeyebilir. Yeni tedavi yerine standart bir tedaviye atanabilirsiniz. <\/p><p><strong>Kat\u0131l\u0131m gereksinimleri<\/strong><\/p><p>E\u011fer a\u015fa\u011f\u0131daki \u00f6zelliklere sahipseniz bu \u00e7al\u0131\u015fma sizin i\u00e7in uygun olabilir:<\/p><ul><li>en az 18 ya\u015f\u0131nda olmak<\/li><li>tekrarlayan d\u00fc\u015f\u00fck dereceli ser\u00f6z over karsinomu te\u015fhisi konmu\u015f olanlar<\/li><li>taramalarda \u00f6l\u00e7\u00fclebilir t\u00fcm\u00f6rlere sahip olmak<\/li><li>fiziksel olarak bir klinik ara\u015ft\u0131rmaya kat\u0131labilecek kadar iyi durumda olanlar<\/li><li>d\u00fczenli t\u0131bbi muayenelerden, kan testlerinden ve di\u011fer sa\u011fl\u0131k de\u011ferlendirmelerinden ge\u00e7meye istekli<\/li><\/ul><div><p><strong>\u00c7al\u0131\u015fmalara nerede kat\u0131labilirim?<\/strong><\/p><div><p>Bu \u00e7al\u0131\u015fma Kuzey Amerika, Avrupa ve di\u011fer b\u00f6lgelerdeki 75&#8217;in \u00fczerinde hastane ve kanser merkezinde y\u00fcr\u00fct\u00fclmektedir. Almanya&#8217;daki lokasyonlar\u0131 Almanya haritam\u0131zda bulabilirsiniz.<\/p><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-798abf5c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"798abf5c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-48eab1f6\" data-id=\"48eab1f6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5b70cfd2 elementor-widget elementor-widget-button\" data-id=\"5b70cfd2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"http:\/\/studienportal-eierstockkrebs.de\/deutschlandkarte\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-right\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M190.5 66.9l22.2-22.2c9.4-9.4 24.6-9.4 33.9 0L441 239c9.4 9.4 9.4 24.6 0 33.9L246.6 467.3c-9.4 9.4-24.6 9.4-33.9 0l-22.2-22.2c-9.5-9.5-9.3-25 .4-34.3L311.4 296H24c-13.3 0-24-10.7-24-24v-32c0-13.3 10.7-24 24-24h287.4L190.9 101.2c-9.8-9.3-10-24.8-.4-34.3z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Almanya haritas\u0131na<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5c415bd2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5c415bd2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-44606060\" data-id=\"44606060\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1109bc55 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1109bc55\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-b7b8d90 e-flex e-con-boxed e-con e-parent\" data-id=\"b7b8d90\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-80aad63 elementor-widget elementor-widget-text-editor\" data-id=\"80aad63\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Bu \u00e7al\u0131\u015fma taraf\u0131ndan desteklenmektedir:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-50a1a78 elementor-widget elementor-widget-image\" data-id=\"50a1a78\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"109\" src=\"https:\/\/studienportal-eierstockkrebs.de\/wp-content\/uploads\/Verastem_tm_rgb-300x109.jpg\" class=\"attachment-medium size-medium wp-image-1879\" alt=\"\" srcset=\"https:\/\/studienportal-eierstockkrebs.de\/wp-content\/uploads\/Verastem_tm_rgb-300x109.jpg 300w, https:\/\/studienportal-eierstockkrebs.de\/wp-content\/uploads\/Verastem_tm_rgb.jpg 480w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-42929674 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"42929674\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-763ea7ac\" data-id=\"763ea7ac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2f8f75df elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"2f8f75df\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e4a28e elementor-widget elementor-widget-text-editor\" data-id=\"1e4a28e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Son g\u00fcncelleme tarihi 05.03.2025<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>AGO-OVAR 2.46 \/ ENGOT-ov81 \/ RAMP 301 TEKRARLAYAN D\u00dc\u015e\u00dcK DERECELI\u0307 SER\u00d6Z OVER KARSI\u0307NOMU \u00dcZERI\u0307NE KLI\u0307NI\u0307K \u00c7ALI\u015eMA AGO-OVAR 2.46 \/ ENGOT-ov81 \/ RAMP 301, tekrarlayan d\u00fc\u015f\u00fck dereceli ser\u00f6z over kanseri (LGSOC) olan hastalarda ara\u015ft\u0131rmac\u0131n\u0131n se\u00e7ti\u011fi tedaviye k\u0131yasla avutometinib ve defaktinib kombinasyon tedavisinin randomize, a\u00e7\u0131k etiketli bir faz III \u00e7al\u0131\u015fmas\u0131d\u0131r. \u00c7al\u0131\u015fman\u0131n amac\u0131 nedir? Bu \u00e7al\u0131\u015fma, \u00f6nceki tedaviden [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[47,46],"tags":[],"class_list":["post-1984","post","type-post","status-publish","format-standard","hentry","category-calismalar","category-nueks"],"acf":[],"_links":{"self":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/comments?post=1984"}],"version-history":[{"count":1,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1984\/revisions"}],"predecessor-version":[{"id":1986,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/posts\/1984\/revisions\/1986"}],"wp:attachment":[{"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/media?parent=1984"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/categories?post=1984"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/studienportal-eierstockkrebs.de\/tr\/wp-json\/wp\/v2\/tags?post=1984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}